Reversible Neonatal Cholestasis Following In Utero Exposure to Valproic Acid
Valproic acid (VPA) is a branched-chain carboxylic acid with broad anticonvulsant activity.Its spectrum of activity is thought to be mediated by combined molecular effects on intercellular Na+ currents, neuron K+ channels, and inhibition of gamma-aminobutyric acid (GABA) transaminase (1,2).VPA is metabolized in the liver by cytochrome P-450 oxidase